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Purdue vs. Iowa State prediction, odds, spread: 2025 college basketball picks from proven model

December 6, 2025
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Unbeaten squads meet in an early tip on Saturday as the top-ranked Purdue Boilermakers host the No. 10 Iowa State Cyclones. Iowa State is off to a strong start with wins over Mississippi State, Creighton, St. John’s and Syracuse already on its resume. Purdue, meanwhile, has knocked off Alabama, Rutgers, Memphis and Texas Tech thus far. Both teams have covered in their last three games as well, setting up a heavyweight, top-10 battle. 

Tipoff from Mackey Arena is set for noon ET. The Boilermakers are 5.5-point favorites in the latest Purdue vs. Iowa State odds, while the over/under is 154.5. Before making any Iowa State vs. Purdue picks, check out the men’s college basketball predictions and betting advice from the SportsLine Projection Model.

You can watch this game on CBS or stream on Paramount+, where you can get a free 7-day trial. Sign up right here.

New users can target the DraftKings promo code, which offers $200 in bonus bets if your $5+ bet wins:

The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,000 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen huge returns.    

Now, the model has simulated Purdue vs. Iowa State 10,000 times and just revealed its coveted men’s college basketball picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several men’s college basketball odds and men’s college basketball betting lines for Iowa State vs. Purdue:

Purdue vs. Iowa State spread:    

Purdue -5.5

Purdue vs. Iowa State over/under:    

154.5 points

Purdue vs. Iowa State money line:    

Purdue -265, ISU +213

Purdue vs. Iowa State picks:    

See picks at SportsLine

Purdue vs. Iowa State streaming:

Paramount+ (Get a free 7-day trial)    

New users can check out the latest bet365 bonus code to get $150 in bonus bets after placing a $5 bet:

How to make Purdue vs. Iowa State picks

SportsLine’s model is going Over on the total (154.5 points). Six out Iowa State’s eight games have gone Over the total this season, including three out of four on the road. Purdue, meanwhile, has seen three of its four home games go Over. 

The model projects that eight players will hit double figures in this game with Iowa State’s Joshua Jefferson and Purdue’s Trey Kaufman-Renn leading their respective sides in scoring. The model projects that the teams combine for 160 points as the Over hits nearly 70% of the time. 

The SportsLine model says one side of the spread hits in over 60% of simulations. You can only see that pick at SportsLine.

So who wins Iowa State vs. Purdue, and which side of the spread hits over 60% of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model was profitable on top-ranked college basketball picks last season, and find out.



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