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College football Week 4 odds, moneyline, spreads and totals

September 16, 2025
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Sep 15, 2025, 12:00 PM ET

The AP Poll is out and Ohio State remain No. 1, Texas A&M moves into the top 10 after their win over Notre Dame. As for Notre Dame, they are still ranked after starting the season 0-2. but no team has ever started the season 0-3 and held onto a top-25 ranking.

There will be three ranked matchups, as No. 17 Texas Tech faces No. 16 Utah, No. 22 Auburn takes on No. 11 Oklahoma, and at night, No. 9 Illinois match up against No. 19 Indiana.

ESPN College Gameday will be in Coral Gables, Florida, as the Florida Gators will look to take down the No. 4 Miami Hurricanes on ABC.

All times Eastern. For latest lines, go to ESPN BET

No. 17 Texas Tech at No. 16 Utah -3.5Saturday, Noon, FOX

Records: Texas Tech 3-0, 0-0 vs. AP teams; Utah 3-0, 0-0 vs. AP teamsOpening Line: Utah -4.5, O/U 56.5Money line: Texas Tech (+155); Utah (-185)Over/Under: 57.5 (O -105, U 115)

FPI Projection Utah by 3.8 points with a 65% probability to win game outright

UAB at No. 15 Tennessee -39.5Saturday, 12:45 p.m., SEC Network

Records: UAB 2-1, 0-0 vs. AP teams; Tennessee 2-1, 0-1 vs. AP teamsOpening Line: Tennessee -37.5, O/U 68.5Money line: OffOver/Under: 67.5 (O -110, U 110)

FPI Projection Tennessee by 36.4 points with a 99% probability to win game outright

Oregon State at No. 6 Oregon -35.5Saturday, 3 p.m.,

Records: Oregon State 0-3, 0-1 vs. AP teams; Oregon 3-0, 0-0 vs. AP teamsOpening Line: Oregon -34.5, O/U 56.5Money line: OffOver/Under: 56.5 (O -120, U VEN)

FPI Projection Oregon by 36.3 points with a 99% probability to win game outright

Kent State at No. 7 Florida State -44.5Saturday, 3:30 p.m., ACC Network

Records: Kent State 1-2, 0-1 vs. AP teams; Florida State 2-0, 1-0 vs. AP teamsOpening Line: Florida State -42.5, O/U 56.5Money line: OffOver/Under: 55.5 (O -115, U 105)

FPI Projection Florida State by 38.5 points with a 99% probability to win game outright

No. 22 Auburn at No. 11 Oklahoma -6.5Saturday, 3:30 p.m., ABC

Records: Auburn 3-0, 0-0 vs. AP teams; Oklahoma 3-0, 1-0 vs. AP teamsOpening Line: Oklahoma -6.5, O/U 49.5Money line: Auburn (+195); Oklahoma (-230)Over/Under: 48.5 (O -115, U -105)

FPI Projection Oklahoma by 3.8 points with a 65% probability to win game outright

Tulane at No. 13 Ole Miss -11.5Saturday, 3:30 p.m., ESPN

Records: Tulane 3-0, 0-0 vs. AP teams; Ole Miss 3-0, 0-0 vs. AP teamsOpening Line: Ole Miss -12.5, O/U 61.5Money line: Tulane (+340); Ole Miss (-450)Over/Under: 61.5 (O -105, U -115)

FPI Projection Ole Miss by 13.8 points with a 87% probability to win game outright

No. 21 Michigan -2.5 at NebraskaSaturday, 3:30 p.m., CBS, Paramount+

Records: Michigan 2-1, 0-1 vs. AP teams; Nebraska 3-0, 0-0 vs. AP teamsOpening Line: Michigan -2.5, O/U 44.5Money line: Michigan (-140); Nebraska (+120)Over/Under: 44.5 (O -115, U -105)

FPI Projection Nebraska by 0.1 points with a 50% probability to win game outright

Purdue at No. 24 Notre Dame -26.5Saturday, 3:30 p.m., NBC, Peacock

Records: Purdue 2-1, 0-0 vs. AP teams; Notre Dame 0-2, 0-2 vs. AP teamsOpening Line: Notre Dame -26.5, O/U 52.5Money line: OffOver/Under: 55.5 (O -105, U -115)

FPI Projection Notre Dame by 20.3 points with a 93% probability to win game outright

Temple at No. 18 Georgia Tech -23.5Saturday, 4:30 p.m., The CW Network

Records: Temple 2-1, 0-1 vs. AP teams; Georgia Tech 3-0, 1-0 vs. AP teamsOpening Line: Georgia Tech -23.5, O/U 53.5Money line: Temple (+1200); Georgia Tech (-3000)Over/Under: 52.5 (O -105, U -115)

FPI Projection Georgia Tech by 18.9 points with a 92% probability to win game outright

South Carolina at No. 23 Missouri -13.5Saturday, 7 p.m., ESPN

Records: South Carolina 2-1, 0-0 vs. AP teams; Missouri 3-0, 0-0 vs. AP teamsOpening Line: Missouri -11.5, O/U 45.5Money line: South Carolina (+380); Missouri (-550)Over/Under: 46.5 (O -115, U -105)

FPI Projection Missouri by 9.5 points with a 80% probability to win game outright

Florida at No. 4 Miami -3Saturday, 7:30 p.m., ABC

Records: Florida 1-2, 0-1 vs. AP teams; Miami 3-0, 2-0 vs. AP teamsOpening Line: Miami -3.5, O/U 52.5Money line: Florida (+135); Miami (-155)Over/Under: 52.5 (O -105, U -115)

FPI Projection Miami by 7.2 points with a 75% probability to win game outright

No. 9 Illinois at No. 19 Indiana -3.5Saturday, 7:30 p.m., NBC

Records: Illinois 3-0, 0-0 vs. AP teams; Indiana 3-0, 0-0 vs. AP teamsOpening Line: Indiana -4.5, O/U 52.5Money line: Illinois (+160); Indiana (-190)Over/Under: 52.5 (O -115, U -105)

FPI Projection Indiana by 3.1 points with a 63% probability to win game outright

Georgia State at No. 20 Vanderbilt -25.5Saturday, 7:30 p.m., ESPNU

Records: Georgia State 1-2, 0-1 vs. AP teams; Vanderbilt 3-0, 1-0 vs. AP teamsOpening Line: Vanderbilt -26.5, O/U 53.5Money line: Georgia State (+1500); Vanderbilt (-5000)Over/Under: 53.5 (O -110, U -110)

FPI Projection Vanderbilt by 30.7 points with a 98% probability to win game outright

SE Louisiana at No. 3 LSUSaturday, 7:45 p.m., SEC Network

Records: SE Louisiana 2-1 (2nd in Southland); LSU 3-0, 1-0 vs. AP teams

No line posted

FPI Projection LSU by 34.9 points with a 98% probability to win game outright

Idaho at No. 8 Texas -41.5Saturday, 8 p.m., ESPN+, SECN+

Records: Sam Houston 2-1, 0-0 vs. AP teams; Texas 2-1, 0-1 vs. AP teamsOpening Line: Texas -40.5, O/U 51.5Money line: OffOver/Under: 51.5 (O -115, U -105)

FPI Projection Texas by 37.7 points with a 99% probability to win game outright

Michigan State at No. 25 USC -17.5Saturday, 11 p.m., FOX

Records: Michigan State 3-0, 0-0 vs. AP teams; USC 3-0, 0-0 vs. AP teamsOpening Line: USC -15.5, O/U 56.5Money line: Michigan State (+550); USC (-900)Over/Under: 56.5 (O -105, U -115)

FPI Projection USC by 24.2 points with a 95% probability to win game outright



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