Duke vs. Louisville prediction, odds, spread: 2026 college basketball picks, best bets

The Duke Blue Devils will visit the Louisville Cardinals on Tuesday’s college basketball schedule as each squad plays its third ACC game of the season. No. 6 Duke (13-1, 2-0 ACC) has won both of its conference matchups by six points or fewer, most recently knocking off Florida State, 91-87, on Saturday. No. 20 Louisville (11-3, 1-1 ACC) is coming off an 80-76 loss to Stanford on Friday, which followed a 20-point blowout win over Cal. Duke has won each of the last seven meetings between the teams. Both teams are 9-5 against the spread this season.

Tipoff is at 7 p.m. ET from the KFC Yum! Center in Louisville, Ky. Duke leads the all-time series 17-9. The Cardinals are 1.5-point favorites in the latest Louisville vs. Duke odds, while the over/under is 161.5. Before making any Duke vs. Louisville picks, check out the men’s college basketball predictions and betting advice from the SportsLine Projection Model.

New users can target the DraftKings promo code, which offers $300 in bonus bets if your $5+ bet wins:

The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 10 on a sizzling 9-1 run on its top-rated over/under college basketball picks dating back to last season. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns. 

Now, the model has simulated Louisville vs. Duke 10,000 times and just revealed its men’s college basketball picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several men’s college basketball odds and men’s college basketball betting lines for Duke vs. Louisville:

Louisville vs. Duke spread:    

Louisville -1.5 at DraftKings Sportsbook

Louisville vs. Duke over/under:    

161.5 points

Louisville vs. Duke money line:    

Duke -110, Louisville -109

Louisville vs. Duke picks:    

See picks at SportsLine

Louisville vs. Duke streaming:

Fubo (Try for free)    

New users can check out the latest bet365 bonus code to get $200 in bonus bets after placing a $5 bet:

How to make Duke vs. Louisville picks

After simulating Louisville vs. Duke 10,000 times, SportsLine’s model is going Under on the total (161.5 points). Duke’s games have heavily leaned under as the Under is 9-5 for the Blue Devils this season thanks to both their wayward outside shooting and tough defense. Duke ranks outside the top 100 teams in the country in 3-point percentage, but on the other end of the court, they’re in the top 20 in the nation in opposing field goal percentage.

As for Louisville, it has seen the Under hit in three of its last four games overall, as well as three of its last four home games. Also, the recent matchups between these two have been low-scoring affairs as each of their last 12 meetings have seen 153 or fewer points scored. SportsLine’s advanced model forecasts 158 combined points on Tuesday as the Under hits nearly 60% of the time.

The model also says one side of the spread hits nearly 60% of the time. You can only see that pick at SportsLine.

So who wins Duke vs. Louisville, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the Louisville vs. Duke spread to back, all from the model that has simulated this matchup 10,000 times, and find out.